Yes you can. You will have to hand in your notice in exactly the same way as you would have done, and it will be up to them whether they say you have to work your notice or not. If you have been on paid leave for a while, there’s a chance that they will say you’re able to leave straight away, because they know that they would have to pay you to be off otherwise. The best thing to do is to talk to your manager about company policy.